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040			_cCICY
090			_aB-14600
245	1	0	_aSynthesis and biological evaluation of cytotoxic properties of stilbene-based resveratrol analogs
490	0		_vEuropean Journal of Medicinal Chemistry, 44(2), p.701-707, 2009
520	3		_aThis work deals with the preparation of stilbene-based resveratrol analogs by employing the Perkin reaction, aiming at synthesizing potential antitumor lead compounds and evaluating their pharmacological activities. The proliferation inhibitor test against tumor cell lines identified analogs 9 and 11 as the most active among all synthesized derivatives, presenting IC50 in micromolar range for certain cell lines. For study on the embryonic development, compounds 8 and 9 at the lowest tested concentration (41.7 mM)that inhibited sea urchin egg development, but only after third cleavage were used. Both the compounds inhibited 100 percent of normal development since first cleavage. These data partially corroborated the results obtained with MTT assay using tumor cell lines. None of the tested compounds revealed hemolytic action in assay with mouse erythrocytes.
650	1	4	_aSTILBENES
650	1	4	_aRESVERATROL ANALOGS
650	1	4	_aCYTOTOXIC PROPERTIES
650	1	4	_aEMBRYONIC DEVELOPMENT
700	1	2	_aRotta, R.
700	1	2	_aMarques, M.R.
700	1	2	_aMontenegro, R.C.
700	1	2	_aVasconcellos, M.C.
700	1	2	_aPessoa, C.
700	1	2	_aDe Moraes M.O.
700	1	2	_aCosta-Lotufo L.V.
700	1	2	_aCosta-Lotufo L.V.
700	1	2	_aNogueira Eberlin, M.
856	4	0	_uhttps://drive.google.com/file/d/1M6iGesr7a6IDfzgOsYf5g7ALjH9tNAYF/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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