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090			_aB-14860
245	1	0	_aTissue Engineering of the TMJ Disc: A Review
490	0		_vTissue Engineering, 12(5), p.1183-1196, 2006
520	3		_aThe potential impact of a tissue-engineered temporomandibular joint (TMJ)disc is immense. Cur-rently, patients suffering from a severely dysfunctional TMJ have few options. Facing the general lack of safe, effective TMJ disc implants, many patients undergo discectomy, a procedure that re-moves the injured TMJ disc in hopes of reducing debilitating symptoms associated with severe TMJ disorders. This procedure may not be ideal as the TMJ is left without an important functional com-ponent. Tissue engineering is a promising approach for the creation of viable, effective implants. The first attempt to investigate TMJ disc cells on a biomaterial was conducted in 1991. The first TMJ tissue-engineered constructs to be tested biochemically and biomechanically were formed in 1994; however, in examining this study in retrospect, it is clear how little TMJ knowledge was avail-able at that time. Within the last 10 to 15 years, multiple studies have investigated critical TMJ disc characteristics, and while this characterization is not complete, these data have created a solid foun-dation for tissue-engineering research. Thus, the last 5 years have yielded core studies investigating the principal elements of tissue engineering: scaffold, cell source, and biological/biomechanical stim-uli. Although TMJ disc tissue engineering is still in its formative years, its future is quite promis-ing. Key studies are now being conducted that will assist in the establishment of a solid TMJ disc tissue-engineering approach. As the challenges of tissue engineering are faced and met, the ultimate goal of creating a functional biological implant nears.
700	1	2	_aAllen, K.D.
700	1	2	_aAthanasiou, K.A.
856	4	0	_uhttps://drive.google.com/file/d/1A0X-2kNqOcjihj7NasiDSkpVGls0ECgK/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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