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090			_aB-14923
245	1	0	_aThe antiviral activity of compounds isolated from Kenyan Carissa edulis (Forssk.)Vahl
490	0		_vJournal of Medicinal Plants Research, 4(15), p.1517-1522, 2010
520	3		_aExtracts of a Kenyan medicinal plant, Carissa edulis (Forssk.)Vahl, were subjected to bioactivity guided phytochemical analysis for identification of biological makers of activity. Pure compounds; lupeol, oleuropein, carissol and ß-amyrin were subsequently isolated. In vitroevaluations of the compounds against viral strains of Herpes simples virustypes 1 revealed a significant activity for lupeolat EC 50 of between 2.98 - 4.2 µg/ml for both sensitive and resistant strains with a high therapeutic index (TI > 38). A concentration of the compound at 10.0 µg/ml was virucidal, reducing viral yields in Vero E6 cells by 98.3
650	1	4	_aANTIVIRAL ACTIVITY
650	1	4	_aLUPEOL
650	1	4	_aCARISSA EDULIS
650	1	4	_aHERPES SIMPLEXVIRUS
700	1	2	_aTolo, F. M.
700	1	2	_aRukunga, G. W.
700	1	2	_aMuli, F. W.
700	1	2	_aOchora, J. M.
700	1	2	_aIrungu, B. N.
700	1	2	_aMuthaura, C. N.
700	1	2	_aWanjiku, C. K.
700	1	2	_aWanjiku, C. K.
700	1	2	_aNgoc, Q.
700	1	2	_aHashimoto, K.
700	1	2	_aAsakawa, Y.
856	4	0	_uhttps://drive.google.com/file/d/1FOkO3sSXWVxDDHoc3PHAfVTrVIaMsRvo/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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