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245	1	0	_aSequencing technologies the next generation
490	0		_vNat Rev Genet, 11(1), p.31-46, 2010
520	3		_aDemand has never been greater for revolutionary technologies that deliver fast, inexpensive and accurate genome information. This challenge has catalysed the development of next-generation sequencing (NGS)technologies. The inexpensive production of large volumes of sequence data is the primary advantage over conventional methods. Here, I present a technical review of template preparation, sequencing and imaging, genome alignment and assembly approaches, and recent advances in current and near-term commercially available NGS instruments. I also outline the broad range of applications for NGS technologies, in addition to providing guidelines for platform selection to address biological questions of interest.
700	1	2	_aMetzker, M.L.
856	4	0	_uhttps://drive.google.com/file/d/1NLSSiwRxr76Ru5_XcBl_Mu0Y8ddPe40y/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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