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245	1	0	_aCHOLINE TRANSPORTER-LIKE1 is required for sieve plate development to mediate long-distance cell-to-cell communication
490	0		_vNature Comminications , 5(4276), p.1-11, 2014
520	3		_aPhloem, a plant tissue responsible for long-distance molecular transport, harbours specific junctions, sieve areas, between the conducting cells. To date, little is known about the molecular framework related to the biogenesis of these sieve areas. Here we identify mutations at theCHER1/AtCTL1locus of Arabidopsis thaliana. The mutations cause several phenotypic abnormalities, including reduced pore density and altered pore structure in the sieve areas associated with impaired phloem function.CHER1encodes a member of a poorly characterized choline transporter-like protein family in plants and animals. We show that CHER1 facilitates choline transport, localizes to the trans-Golgi network, and during cytokinesis is associated with the phragmoplast. Consistent with its function in the elaboration of the sieve areas, CHER1 has a sustained, polar localization in the forming sieve plates. Our results indicate that the regulation of choline levels is crucial for phloem development and conductivity in plants.
700	1	2	_aDettmer, J.
700	1	2	_aUrsache, R.
700	1	2	_aCampilho, A.
700	1	2	_aMiyashima, S.
700	1	2	_aBelevich, I.
700	1	2	_aO'Regan, S.
700	1	2	_aLeroy Mullendore, D.
700	1	2	_aLeroy Mullendore, D.
700	1	2	_aLanz, C.
700	1	2	_aBeverina, L.
700	1	2	_aPapagni, A.
700	1	2	_aSchneeberger, K.
700	1	2	_aWeigel, D.
700	1	2	_aStierhof, Y.
700	1	2	_aMoritz, T.
700	1	2	_aKnoblauch, M.
700	1	2	_aJokitalo, E.
700	1	2	_aHelariutta, Y.
856	4	0	_uhttps://drive.google.com/file/d/1VF9xiy_7l2WnnfkCYlWbFSbkc4kAHT86/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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