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245 1 0 _aNucleolus: Structure and Function
490 0 _vEncyclopedia of Life Science eLS. John Wiley, p.1-9, 2015
520 3 _aThe nucleolus is the nuclear subdomain that assembles ribosomal subunits in eukaryotic cells. The nucleolar organiser regions of chromosomes, which contain the genes for pre-ribosomal ribonucleic acid (rRNA), serve as the foundation for nucleolar structure. The nucleolus disassembles at the beginning of mitosis, its components disperse in various parts of the cell and reassembly occurs during telophase and early G1 phase. Ribosome assembly begins with transcription of pre-rRNA. During transcription, ribosomal and non-ribosomal proteins attach to the rRNA. Subsequently, there is modification and cleavage of pre-rRNA and incorporation of more ribosomal proteins and 5S rRNA into maturing pre-ribosomal complexes. The nucleolus also contains proteins and RNAs that are not related to ribosome assembly and a number of new functions for the nucleolus have been identified. These include assembly of signal recognition particles, sensing cellular stress and transport of human immunodeficiency virus 1 (HIV-1)messenger RNA.
650 1 4 _aNUCLEOLUS
650 1 4 _aRIBOSOME BIOGENESIS
650 1 4 _aPRE-RRNA
650 1 4 _aRNA PROCESSING
650 1 4 _aSNORNAS
700 1 2 _aOlson, Mark Oj
700 1 2 _aDundr, Miroslav
856 4 0 _uhttps://drive.google.com/file/d/1xkrvXkLiloAfXXeuRTMMFPhdn6AhKB1e/view?usp=drivesdk
_zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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