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245	1	0	_aThe coffee genome provides insight into the convergent evolution of caffeine biosynthesis
490	0		_vScience, 345(6201), p.1181-1184, 2014
520	3		_aCaffeine has evolved multiple times among plant species, but no one knows whether these events involved similar genes. Denoeud et al. sequenced the Coffea canephora (coffee)genome and identified a conserved gene order (see the Perspective by Zamir). Although this species underwent fewer genome duplications than related species, the relevant caffeine genes experienced tandem duplications that expanded their numbers within this species. Scientists have seen similar but independent expansions in distantly related species of tea and cacao, suggesting that caffeine might have played an adaptive role in coffee evolution.; Science, this issue p. 1181; see also p. 1124 [PUBLICATION ABSTRACT]Coffee is a valuable beverage crop due to its characteristic flavor, aroma, and the stimulating effects of caffeine. We generated a high-quality draft genome of the species Coffea canephora, which displays a conserved chromosomal gene order among asterid angiosperms. Although it shows no sign of the whole-genome triplication identified in Solanaceae species such as tomato, the genome includes several species-specific gene family expansions, among them N-methyltransferases (NMTs)involved in caffeine production, defense-related genes, and alkaloid and flavonoid enzymes involved in secondary compound synthesis. Comparative analyses of caffeine NMTs demonstrate that these genes expanded through sequential tandem duplications independently of genes from cacao and tea, suggesting that caffeine in eudicots is of polyphyletic origin.
650	1	4	_aGENOME
650	1	4	_aCOFFEA
700	1	2	_aDenoeud, France
700	1	2	_aCarretero-Paulet, Lorenzo
700	1	2	_aDereeper, Alexis
700	1	2	_aDroc, Gaëtan
700	1	2	_aGuyot, Romain
700	1	2	_aPietrella, Marco
700	1	2	_aZheng, Chunfang
700	1	2	_aZheng, Chunfang
700	1	2	_aAnthony, François
700	1	2	_aAprea, Giuseppe
700	1	2	_aAury, Jean-Marc
700	1	2	_aBento, Pascal
700	1	2	_aBernard, Maria
700	1	2	_aBocs, Stéphanie
700	1	2	_aCampa, Claudine
856	4	0	_uhttps://drive.google.com/file/d/1U21K_OqXKpFlORd5-65ucxNakT10rJ4H/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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