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245	1	0	_aEvolution and classification of the CRISPR-Cas systems
490	0		_vNature Reviews MicroBiology, 9(6), p.467-477, 2011
520	3		_aThe CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins)modules are adaptive immunity systems that are present in many archaea and bacteria. These defence systems are encoded by operons that have an extraordinarily diverse architecture and a high rate of evolution for both the cas genes and the unique spacer content. Here, we provide an updated analysis of the evolutionary relationships between CRISPR-Cas systems and Cas proteins. Three major types of CRISPR-Cas system are delineated, with a further division into several subtypes and a few chimeric variants. Given the complexity of the genomic architectures and the extremely dynamic evolution of the CRISPR-Cas systems, a unified classification of these systems should be based on multiple criteria. Accordingly, we propose a 'polythetic' classification that integrates the phylogenies of the most common cas genes, the sequence and organization of the CRISPR repeats and the architecture of the CRISPR-cas loci. © 2011 Macmillan Publishers Limited. All rights reserved.
650	1	4	_aCELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN
650	1	4	_aCLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS CRISPR ASSOCIATED PROTEIN
650	1	4	_aUNCLASSIFIED DRUG
700	1	2	_aMakarova, K.S.
700	1	2	_aHaft, D.H.
700	1	2	_aBarrangou, R.
700	1	2	_aBrouns, S.J.J.
700	1	2	_aCharpentier, E.
700	1	2	_aHorvath, P.
700	1	2	_aMoineau, S.
700	1	2	_aMoineau, S.
700	1	2	_aWolf, Y.I.
700	1	2	_aYakunin, A.F.
700	1	2	_aVan Der Oost, J.
700	1	2	_aKoonin, E.V.
856	4	0	_uhttps://drive.google.com/file/d/1QoGtdaC5srpNJhE8zJi4PJ1SvwGDM7Sl/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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