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090 _aB-16215
245 1 0 _aRNA processing and its regulation: Global insights into biological networks
490 0 _vNature Reviews Genetics, 11(1), p.75-87, 2010
520 3 _aIn recent years views of eukaryotic gene expression have been transformed by the finding that enormous diversity can be generated at the RNA level. Advances in technologies for characterizing RNA populations are revealing increasingly complete descriptions of RNA regulation and complexity; for example, through alternative splicing, alternative polyadenylation and RNA editing. New biochemical strategies to map protein-RNA interactions in vivo are yielding transcriptome-wide insights into mechanisms of RNA processing. These advances, combined with bioinformatics and genetic validation, are leading to the generation of functional RNA maps that reveal the rules underlying RNA regulation and networks of biologically coherent transcripts. Together these are providing new insights into molecular cell biology and disease. © 2010 Macmillan Publishers Limited. All rights reserved.
650 1 4 _aALTERNATIVE SPLICING
650 1 4 _aANIMALS
650 1 4 _aCOMPUTATIONAL BIOLOGY
650 1 4 _aGENE EXPRESSION PROFILING
650 1 4 _aGENE EXPRESSION REGULATION
650 1 4 _aGENE REGULATORY NETWORKS
650 1 4 _aGENETIC VARIATION
650 1 4 _aHUMANS
650 1 4 _aMODELS, BIOLOGICAL
650 1 4 _aMODELS, GENETIC
650 1 4 _aOLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS
650 1 4 _aPOLYADENYLATION
650 1 4 _aRNA
650 1 4 _aRNA EDITING
650 1 4 _aTRANSCRIPTION, GENETIC
700 1 2 _aLicatalosi, D.D.
700 1 2 _aDarnell, R.B.
856 4 0 _uhttps://drive.google.com/file/d/1B-2JW2RDud5DQuS9ryMq4ZGT0hxWTPeY/view?usp=drivesdk
_zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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