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245	1	0	_aMolecular Mechanism for Fungal Cell Wall Recognition by Rice Chitin Receptor OsCEBiP
490	0		_vStructure, 24(7), p.1192-1200, 2016
520	3		_aChitin is the major component of fungal cell wall and serves as a molecular pattern that can be recognized by the receptor OsCEBiP in rice, a lysine motif (LysM)receptor-like protein (RLP), to trigger immune responses. The molecular mechanisms underlying chitin recognition remain elusive. Here we report the crystal structures of the ectodomain of OsCEBiP (OsCEBiP-ECD)in free and chitin-bound forms. The structures reveal that OsCEBiP-ECD contains three tandem LysMs followed by a novel structure fold of cysteine-rich domain. The structures showed that chitin binding induces no striking conformational changes in OsCEBiP. Structural comparison among N-acetylglucosamine (NAG)oligomer-bound LysMs revealed a highly conserved recognition mechanism, which is expected to facilitate study of other LysM-containing proteins for their NAG binding. Modeling study showed that chitin induces OsCEBiP homodimerization in a "sliding mode". Our data provide insights into rice chitin receptor-mediated immunity triggered by fungal cell wall. © 2016 Elsevier Ltd
650	1	4	_aPLANT INNATE IMMUNITY
650	1	4	_aPERCEPTION
650	1	4	_aARABIDOPSIS
650	1	4	_aPROTEINS
650	1	4	_aKINASE
650	1	4	_aCERK1
650	1	4	_aMOTIF
650	1	4	_aCEBIP
650	1	4	_aPEPTIDOGLYCAN
650	1	4	_aDIMERIZATION
700	1	2	_aLiu, S.
700	1	2	_aWang, J.
700	1	2	_aHan, Z.
700	1	2	_aGong, X.
700	1	2	_aZhang, H.
700	1	2	_aChai, J.
856	4	0	_uhttps://drive.google.com/file/d/1VY1fXyhrSlSF8CLI5ZeT7kMg296ybf3X/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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