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090			_aB-16403
245	1	0	_aA nuclear 'fossil' of the mitochondrial d-loop and the origin of modern humans
490	0		_vNature, 378(6556), p.489-492, 1995
520	3		_aMammalian mitochondria! DNA sequences evolve more rapidly than nuclear sequences1. Although the rapid rate of evolution is an advantage for the study of closely related species and populations, it presents a problem in situations where related species, used as outgroups in phylogenetic analyses, have accumulated so much change that multiple substitutions obliterate the phylogenetic information2. However, mitochondrial DNA sequences are frequently inserted into the nuclear genome3, where they presumably evolve as nuclear pseudogene sequences and therefore more slowly than their mitochondria! counterparts. Such sequences thus represent molecular 'fossils' that could shed light on the evolution of the mitochondrial genome and could be used as outgroups in situations where no appropriate outgroup species exist. Here we show that human chromosome 11 carries a recent integration of the mitochondrial control region that can be used to gain further insight into the origin of the human mitochondrial gene pool. © 1995 Nature Publishing Group. All rights reserved.
650	1	4	_aANIMAL
650	1	4	_aBASE SEQUENCE
650	1	4	_aCHROMOSOMES, HUMAN, PAIR 11
650	1	4	_aDNA, MITOCHONDRIAL
650	1	4	_aEVOLUTION, MOLECULAR
650	1	4	_aHOMINIDAE
650	1	4	_aHUMAN
650	1	4	_aMALE
650	1	4	_aMOLECULAR SEQUENCE DATA
650	1	4	_aPAN TROGLODYTES
650	1	4	_aPOLYMERASE CHAIN REACTION
650	1	4	_aPSEUDOGENES
650	1	4	_aRECOMBINATION, GENETIC
650	1	4	_aSPERM HEAD
700	1	2	_aZischler, H.
700	1	2	_aGeisert, H.
700	1	2	_aVon Haeseler, A.
700	1	2	_aPääbo, S.
856	4	0	_uhttps://drive.google.com/file/d/1RouaWR15e7Tip1-Gs2iYkTtix42Ti8bp/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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