000			02194nam a2200397Ia 4500
003			MX-MdCICY
005			20250625160151.0
040			_cCICY
090			_aB-16426
245	1	0	_aEpigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions
490	0		_vCell, 166(2), p.492-505, 2016
520	3		_aThe epigenome orchestrates genome accessibility, functionality, and three-dimensional structure. Because epigenetic variation can impact transcription and thus phenotypes, it may contribute to adaptation. Here, we report 1,107 high-quality single-base resolution methylomes and 1,203 transcriptomes from the 1001 Genomes collection of Arabidopsis thaliana. Although the genetic basis of methylation variation is highly complex, geographic origin is a major predictor of genome-wide DNA methylation levels and of altered gene expression caused by epialleles. Comparison to cistrome and epicistrome datasets identifies associations between transcription factor binding sites, methylation, nucleotide variation, and co-expression modules. Physical maps for nine of the most diverse genomes reveal how transposons and other structural variants shape the epigenome, with dramatic effects on immunity genes. The 1001 Epigenomes Project provides a comprehensive resource for understanding how variation in DNA methylation contributes to molecular and non-molecular phenotypes in natural populations of the most studied model plant.
650	1	4	_aARABIDOPSIS THALIANA
700	1	2	_aKawakatsu T
700	1	2	_aHuang Ss
700	1	2	_aJupe F
700	1	2	_aSasaki E
700	1	2	_aSchmitz Rj
700	1	2	_aUrich Ma
700	1	2	_aCastanon R
700	1	2	_aCastanon R
700	1	2	_aBarragan C
700	1	2	_aHe Y
700	1	2	_aChen H
700	1	2	_aDubin M
700	1	2	_aLee Cr
700	1	2	_aWang C
700	1	2	_aBemm F
700	1	2	_aBecker C
700	1	2	_aO'Neil R
700	1	2	_aO'Malley Rc
700	1	2	_aQuarless Dx
856	4	0	_uhttps://drive.google.com/file/d/1vS9sl-LGz2BTv0ltmHM6yq2sZPkwKqxV/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c50600 _d50600