| 000 | 02427nam a2200337Ia 4500 | ||
|---|---|---|---|
| 003 | MX-MdCICY | ||
| 005 | 20250625160158.0 | ||
| 040 | _cCICY | ||
| 090 | _aB-16813 | ||
| 245 | 1 | 0 | _aRedox regulation of protein tyrosine phosphatases: Structural and chemical aspects |
| 490 | 0 | _vAntioxidants and Redox Signaling, 15(1), p.77-97, 2011 | |
| 520 | 3 | _aProtein tyrosine phosphatases (PTPs)are important targets of the H 2O2 that is produced during mammalian signal transduction. H2O2-mediated inactivation of PTPs also may be important in various pathophysiological conditions involving oxidative stress. Here we review the chemical and structural biology of redox-regulated PTPs. Reactions of H2O2 with PTPs convert the catalytic cysteine thiol to a sulfenic acid. In PTPs, the initially generated sulfenic acid residues have the potential to undergo secondary reactions with a neighboring amide nitrogen or cysteine thiol residue to yield a sulfenyl amide or disulfide, respectively. The chemical mechanisms by which formation of sulfenyl amide and disulfide linkages can protect the catalytic cysteine residue against irreversible overoxidation to sulfinic and sulfonic oxidation states are described. Due to the propensity for back-door and distal cysteine residues to engage with the active-site cysteine after oxidative inactivation, differences in the structures of the oxidatively inactivated PTPs may stem, to a large degree, from differences in the number and location of cysteine residues surrounding the active site of the enzymes. PTPs with key cysteine residues in structurally similar locations may be expected to share similar mechanisms of oxidative inactivation. | |
| 650 | 1 | 4 | _aAMIDE |
| 650 | 1 | 4 | _aCYSTEINE |
| 650 | 1 | 4 | _aDISULFIDE |
| 650 | 1 | 4 | _aHYDROGEN PEROXIDE |
| 650 | 1 | 4 | _aPROTEIN TYROSINE PHOSPHATASEPROTEIN TYROSINE PHOSPHATASE 1B |
| 650 | 1 | 4 | _aPROTEIN TYROSINE PHOSPHATASE SHP 1 |
| 650 | 1 | 4 | _aPROTEIN TYROSINE PHOSPHATASE SHP 2 |
| 650 | 1 | 4 | _aSULFENYL AMIDE |
| 650 | 1 | 4 | _aTHIOL |
| 650 | 1 | 4 | _aUNCLASSIFIED DRUG |
| 700 | 1 | 2 | _aTanner, J.J. |
| 700 | 1 | 2 | _aParsons, Z.D. |
| 700 | 1 | 2 | _aCummings, A.H. |
| 700 | 1 | 2 | _aZhou, H. |
| 700 | 1 | 2 | _aGates, K.S. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1NVdbNp6HCq5efzyRAj1UErCbuNRyQNEZ/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
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