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090			_aB-16817
245	1	0	_aRedox regulation of plant stem cell fate
490	0		_vEMBO Journal, 36(19), p.2844-2855, 2017
520	3		_aDespite the importance of stem cells in plant and animal development, the common mechanisms of stem cell maintenance in both systems have remained elusive. Recently, the importance of hydrogen peroxide (H2O2)signaling in priming stem cell differentiation has been extensively studied in animals. Here, we show that different forms of reactive oxygen species (ROS)have antagonistic roles in plant stem cell regulation, which were established by distinct spatiotemporal patterns of ROS-metabolizing enzymes. The superoxide anion ((Formula presented.)) is markedly enriched in stem cells to activate WUSCHEL and maintain stemness, whereas H2O2 is more abundant in the differentiating peripheral zone to promote stem cell differentiation. Moreover, H2O2 negatively regulates (Formula presented.)biosynthesis in stem cells, and increasing H2O2 levels or scavenging (Formula presented.)leads to the termination of stem cells. Our results provide a mechanistic framework for ROS-mediated control of plant stem cell fate and demonstrate that the balance between (Formula presented.)and H2O2 is key to stem cell maintenance and differentiation.
650	1	4	_aPLANT STEM CELL
650	1	4	_aREACTIVE OXYGEN SPECIES
650	1	4	_aSUPEROXIDE ANION
650	1	4	_aSUPEROXIDE DISMUTASE
650	1	4	_aWUSCHEL
700	1	2	_aZeng, J.
700	1	2	_aDong, Z.
700	1	2	_aWu, H.
700	1	2	_aTian, Z.
700	1	2	_aZhao, Z.
856	4	0	_uhttps://drive.google.com/file/d/1HLGV_YoVkanV8oFbBUi_eY0V4NC0TmJl/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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