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090			_aB-16984
245	1	0	_aThe Biology of CRISPR-Cas: Backward and Forward
490	0		_vCell, 172(6), p.1239-1259, 2018
520	3		_aIn bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR)and CRISPR-associated (Cas)proteins constitute an adaptive immune system against phages and other foreign genetic elements. Here, we review the biology of the diverse CRISPR-Cas systems and the major progress achieved in recent years in understanding the underlying mechanisms of the three stages of CRISPR-Cas immunity: adaptation, crRNA biogenesis, and interference. The ecology and regulation of CRISPR-Cas in the context of phage infection, the roles of these systems beyond immunity, and the open questions that propel the field forward are also discussed. CRISPR-Cas systems provide bacteria and archaea with diverse mechanisms of adaptive immunity, illuminating the evolutionary pressures imposed by selfish genetic elements.
650	1	4	_aCRISPR ASSOCIATED PROTEIN
650	1	4	_aDNA
650	1	4	_aNUCLEIC ACID
650	1	4	_aRNA
700	1	2	_aHille, F.
700	1	2	_aRichter, H.
700	1	2	_aWong, S.P.
700	1	2	_aBratovic, M.
700	1	2	_aRessel, S.
700	1	2	_aCharpentier, E.
856	4	0	_uhttps://drive.google.com/file/d/1DJd2qHDOtUMwaBAbWc7VwI8Wq6S-ulDe/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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