000			01961nam a2200253Ia 4500
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090			_aB-17011
245	1	0	_aOpposite roles of salicylic acid receptors NPR1 and NPR3/NPR4 in transcriptional regulation of plant immunity
490	0		_vCell, 173(6), p.1454-1467.e10, 2018
520	3		_aSalicylic acid (SA)is a plant defense hormone required for immunity. Arabidopsis NPR1 and NPR3/NPR4 were previously shown to bind SA and all three proteins were proposed as SA receptors. NPR1 functions as a transcriptional co-activator, whereas NPR3/NPR4 were suggested to function as E3 ligases that promote NPR1 degradation. Here we report that NPR3/NPR4 function as transcriptional co-repressors and SA inhibits their activities to promote the expression of downstream immune regulators. npr4-4D, a gain-of-function npr4 allele that renders NPR4 unable to bind SA, constitutively represses SA-induced immune responses. In contrast, the equivalent mutation in NPR1 abolishes its ability to bind SA and promote SA-induced defense gene expression. Further analysis revealed that NPR3/NPR4 and NPR1 function independently to regulate SA-induced immune responses. Our study indicates that both NPR1 and NPR3/NPR4 are bona fide SA receptors, but play opposite roles in transcriptional regulation of SA-induced defense gene expression. Salicylic acid receptors NPR1 and NPR3/NPR4 play opposite roles in the transcriptional regulation of plant defense against pathogens.
650	1	4	_aSALICYLIC ACID
700	1	2	_aDing, Y.
700	1	2	_aSun, T.
700	1	2	_aAo, K.
700	1	2	_aPeng, Y.
700	1	2	_aZhang, Y.
700	1	2	_aLi, X.
700	1	2	_aZhang, Y.
856	4	0	_uhttps://drive.google.com/file/d/1Tk7R8JpLHKfOfbnR0dRjNe_NvodhFUyR/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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