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090			_aB-17046
245	1	0	_aIndole core-based Copper (II), Cobalt (II), Nickel (II)and Zinc (II)complexes: Synthesis, spectral and biological study
490	0		_vJournal of Molecular Structure, 1248, p.131410, 2022
520	3		_aIn search of biologically active compounds, we have synthesized new Copper(II), Cobalt(II), Nickel(II)and Zinc(II)metal complexes by the reaction of N'-(4-(diethylamino)-2-hydroxybenzylid-ene)-5-methyl-3-phenyl-1H-indole-2-carbohydrazide (L)with the corresponding metal salts. The synthesized metal complexes are thoroughly characterized by various spectral techniques. The spectral data reveal the octahedral geometry for Copper(II), Cobalt(II)and Nickel(II)complexes and tetrahedral geometry for Zinc(II)complex. All the compounds have been screened for their antibacterial, antifungal, anti-tuberculosis and antioxidant activity. The complexes [Cu(L)(Cl)(H2O)2]and [Co(L)(Cl)(H2O)2]exhibited excellent activity against bacteria E. coli and B. subtilis with MIC-12.50 µg/mL and fungi A. flavus and A. niger with MIC-12.50 µg/mL. Among the screened compounds for anti-tuberculosis activity, the complexes [Cu(L)(Cl)(H2O)2], [Co(L)(Cl)(H2O)2]and [Zn(L)(Cl)] was found to be the most active against M. tuberculosis with a MIC of 3.125 µg/mL. Further, the ligand (L)and its [Cu(L)Cl(H2O)2]and [Co(L)Cl(H2O)2]complexes have shown good scavenging activity.
650	1	4	_aTRANSITION METAL COMPLEXES
650	1	4	_aINDOLE4-(DIETHYLAMINO)SALICYLALDEHYDE
650	1	4	_aANTIMICROBIAL
650	1	4	_aANTI-TUBERCULOSIS
700	1	2	_aYernale, N. G.
700	1	2	_aMatada, B. S.
700	1	2	_aVibhutimath, G. B.
700	1	2	_aBiradar, V. D.
700	1	2	_aKarekal, M. R.
700	1	2	_aUdayagiri, M. D.
700	1	2	_aMathada, M. H.
856	4	0	_uhttps://drive.google.com/file/d/130cV6awH8G1CyzcKUagPS8DngOPQfFC7/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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