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090			_aB-17177
245	1	0	_aThe re-emergence of natural products for drug discovery in the genomics era
490	0		_vNat Rev Drug Discov., 14(2), p.111-129, 2015
520	3		_aNatural products have been a rich source of compounds for drug discovery. However, their use has diminished in the past two decades, in part because of technical barriers to screening natural products in high-throughput assays against molecular targets. Here, we review strategies for natural product screening that harness the recent technical advances that have reduced these barriers. We also assess the use of genomic and metabolomic approaches to augment traditional methods of studying natural products, and highlight recent examples of natural products in antimicrobial drug discovery and as inhibitors of protein-protein interactions. The growing appreciation of functional assays and phenotypic screens may further contribute to a revival of interest in natural products for drug discovery.
650	1	4	_aCHEMICAL SPACE
650	1	4	_aPHARMACOPHORES
650	1	4	_aSTEREOCHEMISTRY
650	1	4	_aMETABOLOMICS
650	1	4	_aMETAGENOMICS
700	1	2	_aHarvey Al
700	1	2	_aEdrada-Ebel R
700	1	2	_aQuinn Rj
856	4	0	_uhttps://drive.google.com/file/d/13dELKee_tMNc4nC5EMccYoAjteUIVp4z/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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