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245 1 0 _aPost-translational quantitation by SRM/MRM: applications in cardiology
490 0 _vExpert Review of proteomics, 15(6), p.477-502, 2018
520 3 _aPost-translational modifications (PTMs)have an important role in the regulation of protein function, localization, and interaction with other molecules. PTMs apply a dynamic control of proteins in both physiological and pathological conditions. The study of disease-specific PTMs allows identifying potential biomarkers and developing effective drugs. Enrichment techniques combined with high-resolution mass spectrometry (MS)/MS analysis provide attractive results on PTM characterization. Selected reaction monitoring/multiple reaction monitoring (SRM/MRM)is a powerful targeted assay for the quantitation and validation of PTMs in complex biological samples.
650 1 4 _aBIOMARKERS
650 1 4 _aCARDIOVASCULAR PROTEOMICS
650 1 4 _aMASS SPECTROMETRY
650 1 4 _aMULTIPLE REACTION MONITORING
650 1 4 _aPOST-TRANSLATIONAL MODIFICATIONS
650 1 4 _aPROTEIN FUNCTION
650 1 4 _aSELECTED REACTION MONITORING
650 1 4 _aTARGETED PROTEOMICS
700 1 2 _aGianazza, E.
700 1 2 _aBanfi, C.
856 4 0 _uhttps://drive.google.com/file/d/1rpVOE-N4gYI667tsHAdVqVmYbdpcPTeI/view?usp=drivesdk
_zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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