000			02347nam a2200433Ia 4500
003			MX-MdCICY
005			20250625160210.0
040			_cCICY
090			_aB-17416
245	1	0	_aA Phytophthora effector suppresses trans-kingdom RNAi to promote disease susceptibility.
490	0		_vCell Host & Microbe, 25(1), p.153-165, 2019
520	3		_aRNA silencing (RNAi)has a well-established role in anti-viral immunity in plants. The destructive eukaryotic pathogen Phytophthora encodes suppressors of RNAi (PSRs), which enhance plant susceptibility. However, the role of small RNAs in defense against eukaryotic pathogens is unclear. Here, we show that Phytophthora infection of Arabidopsis leads to increased production of a diverse pool of secondary small interfering RNAs (siRNAs). Instead of regulating endogenous plant genes, these siRNAs are found in extracellular vesicles and likely silence target genes in Phytophthora during natural infection. Introduction of a plant siRNA in Phytophthora leads to developmental deficiency and abolishes virulence, while Arabidopsis mutants defective in secondary siRNA biogenesis are hypersusceptible. Notably, Phytophthora effector PSR2 specifically inhibits secondary siRNA biogenesis in Arabidopsis and promotes infection. These findings uncover the role of siRNAs as antimicrobial agents against eukaryotic pathogens and highlight a defense/counter-defense arms race centered on trans-kingdom gene silencing between hosts and pathogens.
650	1	4	_aANTI-VIRAL IMMUNITY
650	1	4	_aPHYTOPHTHORA
650	1	4	_aARABIDOPSI
650	1	4	_aSMALL INTERFERING RNAS
650	1	4	_aPLANT GENES
650	1	4	_aSIRNA
650	1	4	_aVIRULENCE
650	1	4	_aBIOGENESIS
650	1	4	_aGENE SILENCING
700	1	2	_aHou, Y.
700	1	2	_aZhai, Y.
700	1	2	_aFeng, L.
700	1	2	_aKarimi, H. Z.
700	1	2	_aRutter, B. D.
700	1	2	_aZeng, L.
700	1	2	_aSeokchoi, D.
700	1	2	_aSeokchoi, D.
700	1	2	_aGu, W.
700	1	2	_aChen, X.
700	1	2	_aYe, W.
700	1	2	_aRoger, W.I.
700	1	2	_aZhai, J.
700	1	2	_aMa, W.
856	4	0	_uhttps://drive.google.com/file/d/1RZpC86SDLYNhFQi80A0s0M3NC6uVYlVj/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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