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003			MX-MdCICY
005			20250625160219.0
040			_cCICY
090			_aB-17878
245	1	0	_aIsolation of 4, 4?-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma.
490	0		_vThe Journal of antibiotics, 72(1), p.34, 2019
520	3		_a4,4?-bond secalonic acid D (4,4?-SAD)is a known compound isolated from the marine-derived fungus Penicillium oxalicum. No study about the antitumor effect of this compound has been reported, except for a few focusing on its bactericidal properties. Herein, we performed an in vitro biology test and found that 4,4?-SAD stimulated the apoptosis of tumor cells in the human hepatocellular carcinoma cell lines PLC/PRF/5 and HuH-7 by activating caspase-3, caspase-8, caspase-9, PARP, p53, and cyclin B1, as well as by regulating the Bax/Bcl-2 ratio. In vivo studies showed that 4,4?-SAD had antitumor efficacy in H22 cell xenograft model. Immunohistochemical analysis revealed that 4,4?-SAD could regulate Bax expression, which is a biomarker of tumor growth. In summary, 4,4?-SAD significantly inhibited tumor growth both in vivo and in vitro.
650	1	4	_aFUNGUS
650	1	4	_aPENICILLIUM OXALICUM
650	1	4	_aCANCER
700	1	2	_aChen, L.
700	1	2	_aLi, Y. P.
700	1	2	_aLi, X. X.
700	1	2	_aLu, Z. H.
700	1	2	_aZheng, Q. H.
700	1	2	_aLiu, Q. Y.
856	4	0	_uhttps://drive.google.com/file/d/1brn43dCWkFGUjZ4cuV3N4qmbsUthrxRd/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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