000			01495nam a2200289Ia 4500
003			MX-MdCICY
005			20250625160220.0
040			_cCICY
090			_aB-17935
245	1	0	_aSynthesis and cytotoxic evaluation of usnic acid benzylidene derivatives as potential anticancer agents
490	0		_vNatural Product Research, p.1-10 https://doi.org/10.1080/14786419.2019.1639176, 2019
520	3		_aA series of usnic acid benzylidene derivatives (groups I-V)were designed, synthesized and evaluated for their anticancer activity in the search for potentially new anticancer agents. Compounds 1a, 5b, 2b, 2e and 2f exhibited the most potent cytotoxcity against K562 cell line with IC50 values of 10.0?±?3.6, 5.6?±?0.4, 8.8?±?1.0, 4.5?±?0.1 and 8.4?±?0.4??M, respectively. It is noteworthy that compound 2e displayed potent cytotoxicity against K562 cells without any cytotoxic effect on HEK293 normal cell line.
650	1	4	_aALDOL CONDENSATION
650	1	4	_aBENZYLIDENE DERIVATIVE
650	1	4	_aCYTOTOXICITY
650	1	4	_aUSNIC ACID
700	1	2	_aNguyen, V. K.
700	1	2	_aSichaem, J.
700	1	2	_aNguyen, H. H.
700	1	2	_aNguyen, X. H.
700	1	2	_aHuynh, T. T. L.
700	1	2	_aNguyen, T. P.
700	1	2	_aNguyen, K. P. P.
856	4	0	_uhttps://drive.google.com/file/d/1DowroXizg8tV5bW4k_Vukk4iXv-hB8ly/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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