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090			_aB-17937
245	1	0	_aEmergent synapse organizers: LAR-RPTPs and their companions.
490	0		_vIn International Review of cell and Molecular Biology. Academic Press., 324, p.39-65, 2016
520	3		_aLeukocyte common antigen-related receptor tyrosine phosphatases (LAR-RPTPs)have emerged as key players that organize various aspects of neuronal development, including axon guidance, neurite extension, and synapse formation and function. Recent research has highlighted the roles of LAR-RPTPs at neuronal synapses in mediating distinct synaptic adhesion pathways through interactions with a host of extracellular ligands and in governing a variety of intracellular signaling cascades through binding to various scaffolds and signaling proteins. In this chapter, we review and update current research progress on the extracellular ligands of LAR-RPTPs, regulation of their extracellular interactions by alternative splicing and heparan sulfates, and their intracellular signaling machineries. In particular, we review structural insights on complexes of LAR-RPTPs with their various ligands. These studies lend support to general molecular mechanisms underlying LAR-RPTP-mediated synaptic adhesion and signaling pathways.
650	1	4	_aLAR
650	1	4	_aPTP
650	1	4	_aPTP
650	1	4	_aSYNAPTIC ADHESIÓN
650	1	4	_aRECEPTOR PROTEIN TYROSINE PHOSPHATASE
650	1	4	_aLIGANDS
650	1	4	_aSYNAPSE DEVELOPMENT
650	1	4	_aALTERNATIVE SPLICING
650	1	4	_aHEPARAN SULFATE
700	1	2	_aHan, K. A.
700	1	2	_aJeon, S.
700	1	2	_aUm, J. W.
700	1	2	_aKo, J.
856	4	0	_uhttps://drive.google.com/file/d/1Q983Q7D947AES_tK2wBMdgg6RElFgb2i/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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