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245	1	0	_aThe structure of a retinal-forming carotenoid oxigenase
490	0		_vScience, 308(5719), p.267-269, 2005
520	3		_aEnzymes that produce retinal and related apocarotenoids constitute a sequence- and thus structure-related family, a member of which was analyzed by x-ray diffraction. This member is an oxygenase and contains an Fe2+-4-His arrangement at the axis of a seven-bladed ?-propeller chain fold covered by a dome formed by six large loops. The Fe2+ is accessible through a long nonpolar tunnel that holds a carotenoid derivative in one of the crystals. On binding, three consecutive double bonds of this carotenoid changed from a straight all-trans to a cranked cis-trans-cis conformation. The remaining trans bond is located at the dioxygen-ligated Fe2+ and cleaved by oxygen.
650	1	4	_aCAROTENOID OXYGENASE
700	1	2	_aKloer, D. P.
700	1	2	_aRuch, S.
700	1	2	_aAl-Babili, S.
700	1	2	_aBeyer, P.
700	1	2	_aSchulz, G. E.
856	4	0	_uhttps://drive.google.com/file/d/1XHMi074oCPi4cltc2APs3zZF0ll04qxt/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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