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040			_cCICY
090			_aB-17999
245	1	0	_aAdvances in the proteomic investigation of the cell secretome
490	0		_vExpert Review of proteomics, 9(3), p.337-345, 2012
520	3		_aStudies of the cell secretome have greatly increased in recent years owing to improvements in proteomic platforms, mass spectrometry instrumentation and to the increased interaction between analytical chemists, biologists and clinicians. Several secretome studies have been implemented in different areas of research, leading to the generation of a valuable secretome catalogs. Secreted proteins continue to be an important source of biomarkers and therapeutic target discovery and are equally valuable in the field of microbiology. Several discoveries have been achieved in vitro using cell culture systems, ex vivo using human tissue specimens and in vivo using animal models. In this review, some of the most recent advances in secretome studies and the fields that have benefited the most from this evolving technology are highlighted.
650	1	4	_aBIOMARKERS
650	1	4	_aCANCER
650	1	4	_aCEREBROSPINAL FLUID
650	1	4	_aEXOSOMES
650	1	4	_aIN VIVO MICRODIALYSIS
650	1	4	_aMASS SPECTROMETRY
650	1	4	_aSECRETOME
650	1	4	_aSERUM
650	1	4	_aSILAC
650	1	4	_aURINE
700	1	2	_aBrown, K. J.
700	1	2	_aFormolo, C. A.
700	1	2	_aSeol, H.
700	1	2	_aMarathi, R. L.
700	1	2	_aDuguez, S.
700	1	2	_aAn, E.
700	1	2	_aHathout, Y.
856	4	0	_uhttps://drive.google.com/file/d/1LyfQy4TIXPNkf-w3MQe48YOh51wMwhEx/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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