000			01212nam a2200265Ia 4500
003			MX-MdCICY
005			20250625160222.0
040			_cCICY
090			_aB-18036
245	1	0	_aSynthesis and biological evaluation of C-13, C-14 modified taxane analogues from 1-deoxybaccatin VI.
490	0		_vNatural Product Research, 33(24), p.3478-3484, 2019
520	3		_aour C-13, C-14 side chain modified 9(R)-hydroxy-1-deoxy-taxane analogues 15, 16, 19 and 22 were semi-synthesized from 1-deoxybaccatin VI. The in vitro antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containing group on C-14 could improve the cytotoxic activities.
650	1	4	_a1-DEOXYBACCATIN VI
650	1	4	_aTAXANE
650	1	4	_aCYTOTOXICITY
650	1	4	_aOXIDATION
650	1	4	_aSYNTHESIS
700	1	2	_aTang, P.
700	1	2	_aLin, H. X.
700	1	2	_aYuan, T. H.
700	1	2	_aCui, Y. M.
856	4	0	_uhttps://drive.google.com/file/d/13_-dOfCiQFwRqElhG1uxktUxkLUAN_6H/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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