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090			_aB-18038
245	1	0	_aSynthesis of halogenated azo-aspirin analogues from natural product derivatives as the potential antibacterial agents.
490	0		_vNatural Product Research, 33(24), p.3507-3514, 2019
520	3		_aChemical modification of medicines from natural product-based molecules has become of interest in recent years. In this study, a series of halogenated azo derivatives 1a-d were synthesised via coupling reaction, followed by Steglich esterification with aspirin (a natural product derivative)to form azo derivatives 2a-d. While, halogenated azo-aspirin 3a-d were synthesised via direct coupling reaction of aspirin and diazonium salt. Bacteriostatic activity was demonstrated against E. coli and S. aureus via turbidimetric kinetic method. Compound 3a-d showed excellent antibacterial activities against E. coli (MIC 75-94 ppm)and S. aureus (MIC 64-89 ppm)compared to ampicillin (MIC 93 and 124 ppm respectively), followed by 1a-d and 2a-d. The presence of reactive groups of -OH, N=N, C=O and halogens significantly contribute excellent interaction towards E. coli and S. aureus. Molecular dockings analysis of 3a against MIaC protein showed binding free energy of ?7.2 kcal/mol (E. coli)and ?6.6 kcal/mol (S. aureus).
650	1	4	_aASPIRIN
650	1	4	_aAZO
650	1	4	_aTURBIDIMETRIC
650	1	4	_aCHEMICAL MODIFICATION
650	1	4	_aANTIBACTERIAL
700	1	2	_aNgaini, Z.
700	1	2	_aMortadza, N. A.
856	4	0	_uhttps://drive.google.com/file/d/1vkicNPGNCMHIku1F02TYgy9I_Tlo6gQe/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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