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| 003 | MX-MdCICY | ||
| 005 | 20250625160226.0 | ||
| 040 | _cCICY | ||
| 090 | _aB-18249 | ||
| 245 | 1 | 0 | _aThe use of a non-cultured autologous cell suspension and Integra® dermal regeneration template to repair full-thickness skin wounds in a porcine model: a one-step process. |
| 490 | 0 | _vBurns, 33(6), p.693-700, 2007 | |
| 520 | 3 | _aIntegra® is a skin substitute used for dermal reconstruction. Current clinical practice consists of two procedures, first applying Integra® to the wound and then replacing the silicone pseudo-epidermis with an epidermal autograft 3 weeks later. This two-step repair limits the clinical use of the product. An effective one-step procedure could reduce the time taken to repair and decrease the number of procedures for use of Integra®. This study examined the effects of simultaneous application of a non-cultured autologous suspension of cells, isolated using the ReCell® autologous cell harvesting device, in combination with Integra®, to achieve a one-step skin repair. In two female Yorkshire swine, 10 full-thickness wounds were created. Wounds were treated with Integra® seeded with cell suspension and compared to controls of Integra® alone and cell suspension alone. Weekly macroscopic and histological assessment demonstrated that the wounds treated simultaneously with Integra® and non-cultured autologous cells had enhanced epithelialization at an early time-point compared to controls. Wounds treated simultaneously with Integra® and cell suspension demonstrate that cells remain viable, migrate through the Integra® template and self-organize into differentiated epidermis. The results indicate that combining Integra® with autologous cells facilitates one-step skin reconstruction of a full-thickness skin wound. | |
| 650 | 1 | 4 | _aBURN INJURY |
| 650 | 1 | 4 | _aDERMAL REGENERATION TEMPLATE |
| 650 | 1 | 4 | _aNON-CULTURED AUTOLOGOUS CELL SUSPENSION |
| 700 | 1 | 2 | _aWood, F. M. |
| 700 | 1 | 2 | _aStoner, M. L. |
| 700 | 1 | 2 | _aFowler, B. V. |
| 700 | 1 | 2 | _aFear, M. W. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1-u4i7GX-EgEoY6Uwvpms9oAZ6E0ZhBgD/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
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