000			02274nam a2200301Ia 4500
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005			20250625160227.0
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090			_aB-18315
245	1	0	_aNew cassane-type diterpenoids from kernels of Caesalpinia bonduc (Linn.)Roxb. and their inhibitory activities on phosphodiesterase (PDE)and nuclear factor-kappa B (NF-?B)expression.
490	0		_vBioorganic Chemistry, 96, p.103573, 2020
520	3		_aIn this paper, chemical investigation on the chloroform soluble fraction of seed kernels of Caesalpinia bonduc resulted in the isolation of five new cassane diterpenoids: norcaesalpinin O (1), norcaesalpinin P (2), caesalpinin MQ (3), caesall O/P (4/5)and seven known compounds (6-12). Compounds structures were elucidated by 1H NMR, 13C NMR, 2D NMR, HR-MS and ECD (electronic circular dichroism)spectral analysis. The characters for new compounds with the presence of an aromatized C ring or demethyl group at C-17 position in the structures were found. By means of bioactive screenings, the inhibitory effect on type-4 phosphodiesterase (PDE4, the target protein of asthma disease)and nuclear factor-kappa B (NF-?B)expression were valued. Compound 1 was found to exhibit moderate inhibitory activity on PDE4 and much better binding affinity than other structures by docking studies for interaction analyzing. Compounds 6, 10 and 11 displayed considerable inhibitory strength against NF-?B expression with inhibitory ratio 48.6 per cent, 42.9 per cent and 37.1 per cent at 10 µM, respectively. The isolation of cassane-type diterpenoids with anti-inflammation activity from C. bonduc implied that this plant might be a good source for anti-inflammation agents finding.
650	1	4	_aCAESALPINIA BONDUC
650	1	4	_aLEGUMINOSAE
650	1	4	_aCASSANE DITERPENOIDS
650	1	4	_aTYPE-4 PHOSPHODIESTERASE
650	1	4	_aNF-?B
700	1	2	_aLiu, T.
700	1	2	_aWang, M.
700	1	2	_aQi, S.
700	1	2	_aShen, X.
700	1	2	_aWang, Y.
700	1	2	_aJing, W.
700	1	2	_aGao, H.
856	4	0	_uhttps://drive.google.com/file/d/1pAVJu0NX0qkgPcwSnULA07CoiIhffiHn/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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