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245	1	0	_aEffect of D-penicillamine in vitro and in vivo on macrophage phagocytosis.
490	0		_vBioChemical Pharmacology, 29(17), p.2273-2278, 1980
520	3		_aPreincubation of rat peritoneal macrophages with D-penicillamine increased their uptake of labelled aggregated human gamma globulin ([125I]AHG)without affecting the rate of degradation of the aggregates. Administration of D-penicillamine (50 mg.kg?1. day?1 p.o.)to normal rats resulted in increased uptake of [25I]AHG by peritoneal macrophages after 4 days of treatment, but not after 14 and 28 days of treatment. In contrast, macrophages from rats with adjuvant arthritis treated with D-penicillamine (50 mg.kg?1. day?1 p.o.)exhibited an increased uptake of [125I]AHG throughout the course of the disease. Administration of D-penicillamine in vivo had no effect on the rate of degradation of [125I]AHG by freshly prepared macrophages. Culture for 24 hr in vitro prior to incubation with [125I]AHG led to a decrease in the rate of degradation of the labelled aggregates by macrophages from untreated or D-penicillamine-treated rats and from rats with adjuvant arthritis, but not by macrophages from D-penicillamine-treated adjuvant arthritic rats. It is suggested that D-penicillamine may exert a stimulatory effect on the reticuloendothelial function during chronic inflammatory disease, and that this effect may be mediated via an interaction with the macrophage plasma membrane.
650	1	4	_aMACROPHAGE
650	1	4	_aPHAGOCYTOSIS
700	1	2	_aBinderup, L.
700	1	2	_aBramm, E.
700	1	2	_aArrigoni-Martelli, E.
856	4	0	_uhttps://drive.google.com/file/d/1rRdwR7xRe_SNmMZ5FbDly7vV-2crxJer/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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