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090			_aB-18345
245	1	0	_aHemostatic granules and dressing prepared from formulations of carboxymethyl cellulose, kappa-carrageenan and polyethylene oxide crosslinked by gamma radiation.
490	0		_vRadiation Physics and Chemistry, 144, p.180-188, 2018
520	3		_aUncontrolled hemorrhage remains a persistent problem especially in anatomical areas where compression and tourniquet cannot be applied. Hemostatic agents are materials which can achieve control of bleeding in acute, life-threatening traumatic coagulopathy. In this study, we prepared biocompatible hydrogel-based hemostat crosslinked by ionizing radiation. Granules made from carboxymethyl cellulose and dressing from kappa carrageenan and polyethylene oxide were characterized by FT-IR, SEM, and gel analysis. Gamma radiation with a dose of 25 kGy was used for sterilization process. Stability studies indicate that the products remain effective with a shelf life of up to 18 months based on accelerated aging. Both hemostatic agents were demonstrated to be effective in vitro blood clotting assays showing a low blood clotting index, high platelet adhesion capacity and accelerated clotting time. Hemostat granules and dressing were also used in a femoral artery rat bleeding model where hemorrhage control was achieved in 90 s without compression and resulted in 100 per cent survival rate after a 7 and 14-day observation.
650	1	4	_aHEMOSTATIC AGENTS
650	1	4	_aHEMORRHAGE CONTROL
650	1	4	_aCARBOXYMETHYL CELLULOSE
650	1	4	_aKAPPA CARRAGEENAN
650	1	4	_aPOLYETHYLENE OXIDE
650	1	4	_aRADIATION CROSSLINKING
700	1	2	_aBarba, B. J. D.
700	1	2	_aAranilla, C. T.
700	1	2	_aRelleve, L. S.
700	1	2	_aCruz, V. R. C.
700	1	2	_aVista, J. R.
700	1	2	_aAbad, L. V.
856	4	0	_uhttps://drive.google.com/file/d/1FvOvN2YtptRjGch1DaAXCTryMfXQk3-J/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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