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090			_aB-18514
245	1	0	_aModulating protein-protein interaction networks in protein homeostasis.
490	0		_vCurrent Opinion in Chemical Biology,, 50, p.55-65, 2019
520	3		_aProtein-protein interactions (PPIs)occur in complex networks. These networks are highly dependent on cellular context and can be extensively altered in disease states such as cancer and viral infection. In recent years, there has been significant progress in developing inhibitors that target individual PPIs either orthosterically (at the interface)or allosterically. These molecules can now be used as tools to dissect PPI networks. Here, we review recent examples that highlight the use of small molecules and engineered proteins to probe PPIs within the complex networks that regulate protein homeostasis. Researchers have discovered multiple mechanisms to modulate PPIs involved in host/viral interactions, deubiquitinases, the ATPase p97/VCP, and HSP70 chaperones. However, few studies have evaluated the effect of such modulators on the target's network or have compared the biological implications of different modulation strategies. Such studies will have an important impact on next generation therapeutics.
650	1	4	_aPROTEIN-PROTEIN INTERACTIONS
650	1	4	_aPROTEIN HOMEOSTASIS
700	1	2	_aZhong, M.
700	1	2	_aLee, G. M.
700	1	2	_aSijbesma, E.
700	1	2	_aOttmann, C.
700	1	2	_aArkin, M. R
856	4	0	_uhttps://drive.google.com/file/d/18wqC8J0diH45L4LPjlLsdCE18AwMYvrl/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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