000			01987nam a2200265Ia 4500
003			MX-MdCICY
005			20250625162414.0
040			_cCICY
090			_aB-18532
245	1	0	_aDesign of a polyacrylamide and gelatin hydrogel as a synthetic extracellular matrix.
490	0		_vInternational Journal of Polymeric Materials and Polymeric BioMaterials, p.1-12., 2020
520	3		_aHydrogels are three-dimensional networks with high water content become soft and elastic mimicking some characteristics of the extracellular matrix. They can be prepared by using either synthetic or natural polymers, therefore, their combination can benefit the overall of the material for a specific biomedical application. In this study, a semi-interpenetrating polymer network hydrogel of polyacrylamide/gelatin (PAM/Gel)with up to 0.3percent of gelatin content was synthesized while evidence of gelatin incorporation was obtained from FTIR and Raman spectroscopy. SEM micrographs show uniform porous structure of PAM/gelatin combined hydrogels. According to the micrographs, the amount of pores decrease with the incorporation of gelatin into the PAM network. The combined hydrogel had the maximum swelling at 37?°C (1,800?±?73percent). Results indicate that PAM/Gel hydrogels are biocompatible (fibroblast viability >70percent)in the presence of extracts and by direct contact method. These hydrogels can be good candidates for soft tissue engineering applications.
650	1	4	_aBIOCOMPATIBILITY
650	1	4	_a}GELATIN
650	1	4	_aHYDROGELS
650	1	4	_aPOLYACRYLAMIDE
700	1	2	_aTorres-García, R.
700	1	2	_aFlores-Estrada, J.
700	1	2	_aCauich-Rodríguez, J. V.
700	1	2	_aFlores-Reyes, M.
700	1	2	_aFlores-Merino, M. V.
856	4	0	_uhttps://drive.google.com/file/d/1UXp8PcAyJFumvkDW1hHo0XOnToknMzlL/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c52682 _d52682