000			01716nam a2200289Ia 4500
003			MX-MdCICY
005			20250625162414.0
040			_cCICY
090			_aB-18533
245	1	0	_aSynthesis and characterization of metformin-pluronic based polyurethanes for controlled drug delivery
490	0		_vInternational Journal of Polymeric Materials and Polymeric BioMaterials, p.1-12., 2020
520	3		_aSegmented polyurethanes (SPU)were synthesized with Pluronic F127 (PLU)as soft segment and 4,4?-methylene-bis(cyclohexyl)diisocyanate (HMDI)and Metformin (Met)as rigid segment (HMDI-Met)while antidiabetic content increased by using 20percet, 30percent, 40percent, and 50percent of rigid segments. The Met incorporation was provided by FTIR, Raman, NMR, and XPS. By increasing the content of rigid segments, the first decomposition temperature tends to increase from 317?°C to 361?°C while Tg was modified from ?80?°C to ?50?°C. Mass loss was observed during accelerated degradation and therefore SPU-PLU-Met can deliver up to 40?µg/30?days of Met. Cytotoxicity test showed no deleterious effect.
650	1	4	_aSEGMENTED
650	1	4	_aPOLYURETHANE
650	1	4	_aMETFORMIN
650	1	4	_aBIOCOMPATIBILITY
700	1	2	_aBonilla-Hernández, M.
700	1	2	_aZapata-Catzin, G. A.
700	1	2	_aCastillo-Cruz, O. D. J.
700	1	2	_aVargas-Coronado, R. F.
700	1	2	_aCervantes-Uc, J. M.
700	1	2	_aXool-Tamayo, J. F.
700	1	2	_aCauich-Rodríguez, J. V.
856	4	0	_uhttps://drive.google.com/file/d/1awBGsMCWNgNGsmWIx9eOsF4aPu1NWIIB/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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