000			01813nam a2200277Ia 4500
003			MX-MdCICY
005			20250625162414.0
040			_cCICY
090			_aB-18545
245	1	0	_aBiomimetic polyurethane-Based fibrous scaffolds
490	0		_vMaterials Letters, 167, p. 9-12, 2016
520	3		_aThe design of biomimetic scaffolds that reproduce the biochemical, mechanical and structural functions of the ECM is a fundamental requirement to develop functional substrate for tissue engineering. To this aim, materials which combine the easy processability and mechanical properties of synthetic polymers with the biochemical cues provided by natural materials, develop positive interaction with cells, enabling tissue regrowth in vivo. In this work, a polyester urethane (NS-BC2000)was synthesised using poly (?-caprolactone)diol (PCL)as macrodiol, 1,4-diisocyanatobutane (BDI)as diisocyanate and N-Boc serinol as chain extender. After Boc cleavage (S-BC2000)to expose free amino groups, a S-BC2000/PEO (80/20 wt./wt.)solution was successfully electrospun fabricating aligned nanofibres with a fibre size of 2.8±0.6 µm. The aligned nanofibres were then functionalised with IKVAV peptide that was covalently bound exploiting the presence of free amino groups on S-BC2000 chains.
650	1	4	_aBIOMIMETIC
650	1	4	_aFUNCTIONALISATION
650	1	4	_aELECTROSPINNING
650	1	4	_aPEPTIDE
650	1	4	_aPOLYESTER URETHANE
700	1	2	_aTonda-Turo, C.
700	1	2	_aBoffito, M.
700	1	2	_aCassino, C.
700	1	2	_aGentile, P.
700	1	2	_aCiardelli, G.
856	4	0	_uhttps://drive.google.com/file/d/1WKOM9Lud_4OpxovnvnleEGmRdtOuy0_t/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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