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090			_aB-18609
245	1	0	_aA systematic strategy for uncovering quality marker of Asari Radix et Rhizoma on alleviating inflammation based chemometrics analysis of components.
490	0		_vJournal of Chromatography A, 1642, p.461960, 2021
520	3		_aAsari Radix et Rhizoma (Asarum), a traditional Chinese medicine (TCM), has been applied in clinical generally. However, due to the lack of valid methods for Asarum quality control, inhomogenous quality and therapy issues have become severe with each passing day. In this study, we aimed to establish a comprehensive multi-system to explore the quality control markers underlying pharmaceutical effects based on chemometrics analysis on the total ingredients of Asarum. In brief, DNA barcoding technology was used to screen out the unadulterated herbs in the 15 batches Asarum collected from different origins. Then, the chemical profiles of volatile/nonvolatile components of 10 batches Asarum with definite resource were obtained by HPLC Q-TOF/MS and GC/MS. Combination with chemometrics methods, 14 characteristic ingredients and 4 qualitative and quantitative markers were figured out preliminarily. Moreover, correlation analysis between the characteristic ingredients and the cytokines integrating the virtual targets prediction of network pharmacology, 3 potential bioactive substance were ascertained. In conclusion, l-asarinin, 2-Methoxy-4-vinylphenol and safrole were considered as the potent candidates for quality control markers based on the comprehensive understanding for therapeutic effects and the chemical information of Asarum, which provided a novel perspective of the development for the quality control of TCM.
650	1	4	_aASARI RADIX ET RHIZOMA
650	1	4	_aCHEMOMETRICS ANALYSIS
650	1	4	_aCHEMICAL INFORMATION
650	1	4	_aPHARMACODYNAMIC
650	1	4	_aQUALITY CONTROL
700	1	2	_aZhang, Y.
700	1	2	_aLi, S.
700	1	2	_aLiang, Y.
700	1	2	_aLiu, R.
700	1	2	_aLv, X.
700	1	2	_aZhang, Q.
700	1	2	_aLi, Q.
856	4	0	_uhttps://drive.google.com/file/d/1FrZEV-ktSsQQiWaKacljC5PozhBtJ-yV/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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