000			02644nam a2200337Ia 4500
003			MX-MdCICY
005			20250625162418.0
040			_cCICY
090			_aB-18769
245	1	0	_aAn atlas of wheat epigenetic regulatory elements reveals subgenome divergence in the regulation of development and stress responses
490	0		_vThe Plant Cell, 33, p.865-881, 2021
520	3		_aWheat (Triticum aestivum)has a large allohexaploid genome. Subgenome-divergent regulation contributed to genome plasticity and the domestication of polyploid wheat. However, the specificity encoded in the wheat genome determining subgenome-divergent spatio-temporal regulation has been largely unexplored. The considerable size and complexity of the genome are major obstacles to dissecting the regulatory specificity. Here, we compared the epigenomes and transcriptomes from a large set of samples under diverse developmental and environmental conditions. Thousands of distal epigenetic regulatory elements (distal-epiREs)were specifically linked to their target promoters with coordinated epigenomic changes. We revealed that subgenome-divergent activity of homologous regulatory elements is affected by specific epigenetic signatures. Subgenome-divergent epiRE regulation of tissue specificity is associated with dynamic modulation of H3K27me3 mediated by Polycomb complex and demethylases. Furthermore, quantitative epigenomic approaches detected key stress responsive cis- and trans-acting factors validated by DNA Affinity Purification and sequencing, and demonstrated the coordinated interplay between epiRE sequence contexts, epigenetic factors, and transcription factors in regulating subgenome divergent transcriptional responses to external changes. Together, this study provides a wealth of resources for elucidating the epiRE regulomics and subgenome-divergent regulation in hexaploid wheat, and gives new clues for interpreting genetic and epigenetic interplay in regulating the benefits of polyploid wheat.
700	1	2	_aMeiyue Wang
700	1	2	_aZijuan Li
700	1	2	_aYu'E Zhang
700	1	2	_aYuyun Zhang
700	1	2	_aYilin Xie
700	1	2	_aLuhuan Ye
700	1	2	_aYili Zhuang
700	1	2	_aYili Zhuang
700	1	2	_aFei Zhao
700	1	2	_aJingyu Guo
700	1	2	_aWan Teng
700	1	2	_aWenli Zhang
700	1	2	_aYiping Tong
700	1	2	_aYongbiao Xue
700	1	2	_aYijing Zhang
856	4	0	_uhttps://drive.google.com/file/d/1tn5awcy6dIXKOkN79pRdz6kgOwtd84lu/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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