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090			_aB-18817
245	1	0	_aThe origin of genomic N 6-methyl-deoxyadenosine in mammalian cells.
490	0		_vNature Chemical Biology, 16(6), p.630-634, 2020
520	3		_aThe proposal that N6-methyl-deoxyadenosine (m6dA)acts as an epigenetic mark in mammals remains controversial. Using isotopic labeling coupled to ultrasensitive mass spectrometry, we confirm the presence of low-level m6dA in mammalian DNA. However, the bulk of genomic m6dA originates from ribo-N6-methyladenosine, which is processed via the nucleotide-salvage pathway and misincorporated by DNA polymerases. Our results argue against m6dA acting as a heritable, epigenetic DNA mark in mammalian cells.
700	1	2	_aMusheev, M. U.
700	1	2	_aBaumgärtner, A.
700	1	2	_aKrebs, L.
700	1	2	_aNiehrs, C.
856	4	0	_uhttps://drive.google.com/file/d/1iS-MxnhZqutIsVt8Y2XVhJe8bPuv38ys/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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