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| 003 | MX-MdCICY | ||
| 005 | 20250625162419.0 | ||
| 040 | _cCICY | ||
| 090 | _aB-18833 | ||
| 245 | 1 | 0 | _aNovel non-cytotoxic, bioactive and biodegradable hybrid materials based on polyurethanes/TiO2 for biomedical applications. |
| 490 | 0 | _vMaterials Science and Engineering: C, 75, p.375-384, 2017 | |
| 520 | 3 | _aTitanium compounds have demonstrated great interfacial properties with biological tissues whereas a wide variety of polyurethanes have also been successfully probed in medical applications. However, studies about hybrids based on polyurethanes/TiO for medical applications are scarce. The aim of this work is to design novel biodegradable hybrid materials based on polyurethanes/TiO (80percent organic-20percent inorganic)and to perform a preliminary study of the potential applications in bone regeneration. The hybrids have been prepared by a sol-gel reaction using titanium isopropoxide as precursor of the inorganic component and polyurethane as the organic one. A series of polyurethanes has been prepared using different polyesters glycol succinate as soft segment, and 1,6-diisocyanatohexane (HDI)and butanediol (BD)as linear hard segment. The spectroscopy techniques used allow to confirm the formation of the required polyurethanes by the identification of bands related to carboxylic groups (-COOH), and the amine groups (-NH-), and also the Ti-OH bonds and the bonds related to the interconnected network between the inorganic and the organic components from hybrids. The results from SEM/EDS show a homogeneous distribution of the inorganic component into the organic matrix. The nontoxic character of the hybrid (H400)was probed using MG-63 cell line with over 90percent of cell viability. Finally, the formation of a hydroxyapatite layer in the material surface after 21 days of soaking in SBF shows the bioactive character. | |
| 700 | 1 | 2 | _aGonzález-García, D. M. |
| 700 | 1 | 2 | _aJurado, L. T. |
| 700 | 1 | 2 | _aJiménez-Gallegos, R. |
| 700 | 1 | 2 | _aRodríguez-Lorenzo, L. M. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1vhu39y8NxxYOgMmN2s6G7ouqq1gzRHSM/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
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