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| 245 | 1 | 0 | _aOdorant-binding proteins of mammals |
| 490 | 0 | _vBiological Reviews, 97(1), p.20-44, 2022 | |
| 520 | 3 | _aOdorant-binding proteins (OBPs)of vertebrates belong to the lipocalin superfamily and perform a dual function: solubilizing and ferrying volatile pheromones to the olfactory receptors, and complexing the same molecules in specialized glands and assisting their release into the environment. Within vertebrates, to date they have been reported only in mammals, apart from two studies on amphibians. Based on the small number of OBPs expressed in each species, on their sites of production outside the olfactory area and their presence in biological fluids known to be pheromone carriers, such as urine, saliva and sexual secretions, we conclude that OBPs of mammals are specifically dedicated to pheromonal communication. This assumption is further supported by the observation that some OBPs present in biological secretions are endowed with their own pheromonal activity, adding renewed interest to these proteins. Another novel piece of evidence is the recent discovery that glycosylation and phosphorylation can modulate the binding activity of these proteins, improving their affinity to pheromones and narrowing their specificity. A comparison with insects and other arthropods shows a completely different scenario. While mammalian OBPs are specifically tuned to pheromones, those of insects, which are completely different in sequence and structure, include carriers for general odorants in addition to those dedicated to pheromones. Additionally, whereas mammals adopted a single family of carrier proteins for chemical communication, insects and other arthropods are endowed with several families of semiochemical-binding proteins. Here, we review the literature on the structural and functional properties of vertebrate OBPs, summarize the most interesting new findings and suggest possible exciting future developments. | |
| 650 | 1 | 4 | _aCHEMICAL COMMUNICATION |
| 650 | 1 | 4 | _aMAMMALS |
| 650 | 1 | 4 | _aODORANT-BINDING PROTEINS |
| 650 | 1 | 4 | _aOLFACTION |
| 650 | 1 | 4 | _aPHEROMONES |
| 650 | 1 | 4 | _aSALIVARY PROTEINS |
| 650 | 1 | 4 | _aURINARY PROTEINS |
| 700 | 1 | 2 | _aPelosi, P. |
| 700 | 1 | 2 | _aKnoll, W. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1YUiyRANHu_k0eIrV3X48sGEuxx2XfjlV/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
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