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090			_aB-19193
245	1	0	_aSyntheses, structural characterization and evaluation of the anti-tubercular activity of copper (II)complexes containing 3-methoxysalicylaldehyde-4-methylthiosemicarbazone
490	0		_vJournal of Molecular Structure, 1257, p.132589, 2022
520	3		_aIn the present work three novel copper (II)complexes ([CuL(CH3COO)] (1), [CuL(phen)] (2)and [CuL(bpy)] (3)(where phen=1,10-phenanthroline; bpy=2,2? bipyridyl)) containing 3-methoxysalicylaldehyde-4-methylthiosemicarbazone (HL)were synthesised and characterised. All the complexes were characterized using spectral techniques like FT-IR, ESI-MS, TGA-DTA, UV-Vis, ESR and VSM. The structure of complex 2 was confirmed by single-crystal X-ray structure determination. Complex 2 crystallized in a monoclinic crystal system and P 21/n space group with a distorted square pyramidal geometry. In vitro anti-TB and cytotoxicity studies were also carried out using MABA (Microplate Alamar Blue Assay)and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide)assay respectively. All the copper (II)complexes have shown excellent anti-TB properties in the nano-molar concentration range and exhibit low cytotoxicity.
650	1	4	_aCOPPER COMPLEX
650	1	4	_aTHIOSEMICARBAZONE
650	1	4	_aSINGLE-CRYSTAL X-RAY DIFFRACTION
650	1	4	_aMYCOBACTERIUM TUBERCULOSIS H37RV
650	1	4	_aINHIBITION
650	1	4	_aCYTOTOXICITY
650	1	4	_aSELECTIVITY INDEX
700	1	2	_aHegde, P. L.
700	1	2	_aBhat, S. S.
700	1	2	_aRevankar, V. K.
700	1	2	_aShaikh, S. A.
700	1	2	_aKumara, K.
700	1	2	_aLokanath, N. K.
856	4	0	_uhttps://drive.google.com/file/d/1M3l0o1eV5cvEWfAmxFfdVIEVMKPw3x7d/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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