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090			_aB-19246
245	1	0	_aFour new phenolic compounds from the tender leaves of Eucommia ulmoides Oliv. and their anti-inflammatory activities
490	0		_vPhytoChemistry Letters, 44, p.173-177, 2021
520	3		_aFour new phenolic compounds, 2-{[3-(3,4-dihydroxyphenyl)propanoyl]oxy}propanoic acid (1), 2-{[3-(3,4- dihydroxyphenyl)propanoyl]oxy}propanoic acid methyl (2), (±)3-{2-[1-(3? ,4? -dihydroxy-phenyl)ethyl]-4,5- dihydroxyphenyl}propanoic acid methyl (3), and (±)3-{2-[1-(3? ,4? -dihydroxy-phenyl)ethyl]-4,5-dihydroxyphenyl}propanoic acid (4), together with five known compounds, methyl 3-(3,4-dihydroxyphenyl)-propanoate (5), 3,4-dihydroxybenzenepropionic acid (6), caffeic acid (7), protocatechuic acid (8), and 1,3-trans-5,6-dihydroxy-3-(3? ,4? -dihydroxyphenyl)indan-1-methyl (9)were isolated from the tender leaves of Eucommia ulmoides Oliv. Compound 9 was isolated from Eucommiaceae for the first time. The structures of the new compounds were elucidated from the spectra of 1D NMR and 2D NMR, and MS data. Compounds 1-9 were tested to determine their inhibitory effect on LPS-induced NO production in macrophage RAW264.7 cells. Modest inhibitory activities were observed for compounds 2-5 and 9, with IC50 values ranging from 8.3 to 31.0 ?M. This research enriches the current chemical information regarding the leaves of Eucommia ulmoides Oliv. and provides a reference for further research on its anti-inflammatory effects.
650	1	4	_aTENDER LEAVES OF EUCOMMIA ULMOIDES
650	1	4	_aPHENOLICS
650	1	4	_aANTI-INFLAMMATORY ACTIVITY
700	1	2	_aRen, X. M.
700	1	2	_aHan, Z. Z.
700	1	2	_aSong, L. X.
700	1	2	_aLv, Z. Y.
700	1	2	_aYang, Y. B.
700	1	2	_aXiao, Y.
700	1	2	_aZhang, Z. J.
856	4	0	_uhttps://drive.google.com/file/d/1fNYDce8WsL4GwCS4lKA1CM2xnaqFIeRG/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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