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245	1	0	_aCentral nervous system effects and chemical composition of two subspecies of Agastache mexicana; an ethnomedicine of Mexico
490	0		_vJournal of EthnoPharmacology, 153(1), p.98-110, 2014
520	3		_aEthnopharmacological relevance: Agastache mexicana subspecies mexicana (Amm)and xolocotziana (Amx)are used in Mexican traditional medicine to relief cultural affiliation syndromes known as "susto" or "espanto", for "nervous" condition, and as a sleep aid. Despite its intensive use, neuropharmacological studies are scarce, and the chemical composition of the aqueous extracts has not been described. Aims of the study are: (1)To analyze the chemical composition of aqueous extracts from aerial parts of Amm and Amx. (2)To evaluate the anxiolytic-like, sedative, antidepressant-like effects. (3)Analyze the general toxic effects of different doses. Materials and methods: Anxiolytic-like and sedative effects were measured in the avoidance exploratory behavior, burying behavior and the hole-board tests. The antidepressant-like actions were studied in the forced swimming and tail suspension tests. Finally, general activity and motor coordination disturbances were evaluated in the open field, inverted screen and rota-rod tests. The acute toxicity of Amm and Amx was determined by calculating their LD50 (mean lethal dose). The chemical analyses were performed employing chromatographic, photometric and HPLC-ESI-MS techniques. Results: Low doses of Amm and Amx (0.1?1.0mg/kg)induced anxiolytic-like actions; while higher doses (over 10mg/kg)induced sedation and reduced the locomotor activity, exerting a general inhibition in the central nervous system (CNS). Conclusions: Results support the use of Amm and Amx in traditional medicine as tranquilizers and sleep inducers. Additionally, this paper contributes to the knowledge of the chemical composition of the aqueous extracts of these plants.
650	1	4	_aAGASTACHE MEXICANA SPP. MEXICANA
650	1	4	_aAGASTACHE MEXICANA SSP. XOLOCOTZIANA
650	1	4	_aANXIETY
650	1	4	_aCULTURAL AFFILIATION SYNDROMES
650	1	4	_aTORONJIL BLANCO
650	1	4	_aTORONJIL MORADO
700	1	2	_aEstrada-Reyes, R.
700	1	2	_aLópez-Rubalcava, C.
700	1	2	_aFerreyra-Cruz, O. A.
700	1	2	_aDorantes-Barrón, A. M.
700	1	2	_aHeinze, G.
700	1	2	_aAguilar, J. M.
700	1	2	_aMartínez-Vázquez, M.
856	4	0	_uhttps://drive.google.com/file/d/1t8Q2Uu9b_anR8P6_VjITm6TN-qenhWOJ/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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