| 000 | 02279nam a2200313Ia 4500 | ||
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| 003 | MX-MdCICY | ||
| 005 | 20250625162429.0 | ||
| 040 | _cCICY | ||
| 090 | _aB-19341 | ||
| 245 | 1 | 0 | _aThe production of broad-spectrum antibiotics from phytopathogen Epicoccum sorghinum by culturing in host edible mushroom Thelephora ganbajun extract |
| 490 | 0 | _vPhytoChemistry, 200, p.113221, 2022 | |
| 520 | 3 | _aMetabolism of special endophytes and phytopathogens can be induced by the symbiotic interactions with the host. A phytopathogen Epicoccum sorghinum cultured in host mushroom Thelephora ganbajun medium exhibited different metabolites compared with that of ordinary medium. An unprecedented scaffold possessing the same substructure as perylenequinone mycotoxin, a first methyl rearrangement product of phytotoxin, epoxydon 6-methylsalicylate ester, three undescribed compounds, and an undescribed natural product were isolated from E. sorghinum cultured in T. ganbajun. Episorin A and epicosorin A were produced from E. sorghinum induced by culturing in host medium. Episorin A was the first example of perylenequinone analogue in the natural products. These induced compounds and other metabolites showed notable antibiosis against endogenous fungi, and insect existing in mushroom. Induced episorin A showed significant inhibitory effects on nitric oxide production in LPS-activated macrophages, and anti-acetylcholinesterase with the IC50 at 5.40 ± 0.25 ?M, and 4.32 ?M, respectively, and cytotoxicity against HL-60, A-549, SMMC-7721, MCF-7 and SW480 with IC50 at 14.21 ± 0.53, 17.93 ± 0.22, 18.17 ± 0.63, 28.36 ± 0.43, and 18.20 ± 1.03 ?M. | |
| 650 | 1 | 4 | _aBROAD-SPECTRUM ANTIBIOSIS |
| 650 | 1 | 4 | _aDIDYMELLACEAE |
| 650 | 1 | 4 | _aEPICOCCUM SORGHINUM |
| 650 | 1 | 4 | _aINTERACTION |
| 650 | 1 | 4 | _aMETABOLITE |
| 650 | 1 | 4 | _aTHELEPHORA GANBAJUN |
| 650 | 1 | 4 | _aTHELEPHORACEAE |
| 700 | 1 | 2 | _aWang, C. F.Yang, X. Q. |
| 700 | 1 | 2 | _aShi, W. Z. |
| 700 | 1 | 2 | _aLong, X. |
| 700 | 1 | 2 | _aSu, S. |
| 700 | 1 | 2 | _aCen, R. H. |
| 700 | 1 | 2 | _aDing, Z. T. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1HFc0iaBKpni1AIai1nqRnRrT4YE8ZZpU/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
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