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090			_aB-19414
245	1	0	_aPhytochemistry and medicinal plants
490	0		_vPhytoChemistry, 56, p.237-243, 2001
520	3		_aA truncated history of the contribution of plants to medicine is given with reference to some of the less well known ancestors of the Harborne family. Six of the top 20 prescriptions dispensed in 1996 were natural products and the clinical use of drugs such as artemisinin, etoposide and taxol has once more focussed attention on plants as sources of novel drug entities. High through-put robotic screens have been developed by industry and it is possible to carry out 50,000 tests per day in the searc for compounds which have speci®city of action against a key enzyme or a subset of receptors. Bioassay-guided fractionation of plant extracts linked to chromatographic separation techniques leads to the isolation of biologically active molecules whose chemical structures can readily be determined by modern spectroscopic methods. The role of academics in the search for new drugs is discussed by reference to some of our research into natural products with activity on the central nervous system, on pain receptors, the malaria parasite Plasmodium falciparum, the wound healing properties of the sap of species of Croton (Dragon's blood), and a traditional Chinese medicine used to treat eczema. Expertise in phytochemistry has been essential for this research and the strong lead shown by Pro- fessor Je_rey Harborne is gratefully acknowledged.
650	1	4	_aJ.B. HARBORNE
650	1	4	_aMEDICINAL PLANTS
650	1	4	_aPHYTOCHEMISTRY
650	1	4	_aACADEMICS
650	1	4	_aNEW DRUGS
650	1	4	_aCENTRAL NERVOUS SYSTEM
650	1	4	_aECZEMA
650	1	4	_aMALARIA
650	1	4	_aPAIN
650	1	4	_aWOUND HEALING
700	1	2	_aPhillipson, J.D.
856	4	0	_uhttps://drive.google.com/file/d/1JkmGWDNToEe2aWM8nvsugT2_FnomZTDJ/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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