| 000 | 02399nam a2200229Ia 4500 | ||
|---|---|---|---|
| 003 | MX-MdCICY | ||
| 005 | 20250625162434.0 | ||
| 040 | _cCICY | ||
| 090 | _aB-19629 | ||
| 245 | 1 | 0 | _a3´UTRs of carmoviruses |
| 490 | 0 | _vVirus Research, 206, p.27-36, 2015 | |
| 520 | 3 | _aCarmovirus is a genus of small, single-stranded, positive-strand RNA viruses in the Tombusviridae. One member of the carmoviruses, Turnip crinkle virus (TCV), has been used extensively as a model for examining the structure and function of RNA elements in 3'UTR as well as in other regions of the virus. Using a variety of genetic, biochemical and computational methods, a structure for the TCV 3'UTR has emerged where secondary structures and tertiary interactions combine to adopt higher order 3-D structures including an internal, ribosome-binding tRNA-shaped configuration that functions as a 3' cap-independent translation enhancer (3'CITE). The TCV 3'CITE also serves as a scaffold for non-canonical interactions throughout the 3'UTR and extending into the upstream open reading frame, interactions that are significantly disrupted upon binding by the RNA-dependent RNA polymerase. Long-distance interactions that connect elements in the 3'UTR with both the 5' end and the internal ribosome recoding site suggest that 3'UTR of carmoviruses are intimately involved in multiple functions in the virus life cycle. Although carmoviruses share very similar genome organizations, lengths of 5' and 3'UTRs, and structural features at the 3' end, the similarity rapidly breaks down the further removed from the 3' terminus revealing different 3'CITEs and unique virus-specific structural features. This review summarizes 20 years of work dissecting the structure and function of the 3'UTR of TCV and other carmoviruses. The astonishing structural complexity of the 3'UTRs of these simple carmoviruses provides lessons that are likely applicable to many other plant and animal RNA viruses. | |
| 650 | 1 | 4 | _aCAP-INDEPENDENT TRANSLATION |
| 650 | 1 | 4 | _aCARMOVIRUS |
| 650 | 1 | 4 | _aRNA STRUCTURE/FUNCTION |
| 650 | 1 | 4 | _aSATELLITE RNAS |
| 650 | 1 | 4 | _aTURNIP CRINKLE VIRUS |
| 700 | 1 | 2 | _aSimon, A. E. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/10NEs0f4g6QB6Fn_h5RlxtKuiGevdxtG6/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 |
_2Loc _cREF1 |
||
| 008 | 250602s9999 xx |||||s2 |||| ||und|d | ||
| 999 |
_c53752 _d53752 |
||