000			01989nam a2200205Ia 4500
003			MX-MdCICY
005			20250625162435.0
040			_cCICY
090			_aB-19671
245	1	0	_aAn engineered pathway for N-hydroxy-pipecolic acid synthesis enhances systemic acquired resistance in tomato
490	0		_vScience Signaling, 12(604), p.eaay3066, 2019
520	3		_aSystemic acquired resistance (SAR)is a powerful immune response that triggers broad-spectrum disease resistance throughout a plant. In the model plant Arabidopsis thaliana, long-distance signaling and SAR activation in uninfected tissues occur without circulating immune cells and instead rely on the metabolite N-hydroxy-pipecolic acid (NHP). Engineering SAR in crop plants would enable external control of a plant's ability to mount a global defense response upon sudden changes in the environment. Such a metabolite-engineering approach would require the molecular machinery for producing and responding to NHP in the crop plant. Here, we used heterologous expression in Nicotiana benthamiana leaves to identify a minimal set of Arabidopsis genes necessary for the biosynthesis of NHP. Local expression of these genes in tomato leaves triggered SAR in distal tissues in the absence of a pathogen, suggesting that the SAR trait can be engineered to enhance a plant's endogenous ability to respond to pathogens. We also showed tomato produces endogenous NHP in response to a bacterial pathogen and that NHP is present across the plant kingdom, raising the possibility that an engineering strategy to enhance NHP-induced defenses could be possible in many crop plants.
700	1	2	_aHolmes, E. C.
700	1	2	_aChen, Y. C.
700	1	2	_aSattely, E. S.
700	1	2	_aMudgett, M. B.
856	4	0	_uhttps://drive.google.com/file/d/1_naEq-zWbYhu_tY9b3rX-YuVqt8cf-iB/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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