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005			20250625162436.0
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090			_aB-19766
245	1	0	_aCurrent and future approaches for in vitro hit discovery in diabetes mellitus
490	0		_vDrug Discovery Today, 27(10), p.1-13, 2022
520	3		_aType 2 diabetes mellitus (T2DM)is a serious public health problem. In this review, we discuss current and promising future drugs, targets, in vitro assays and emerging omics technologies in T2DM. Importantly, we open the perspective to image-based high-content screening (HCS), with the focus of combining it with metabolomics or lipidomics. HCS has become a strong technology in phenotypic screens because it allows comprehensive screening for the cell-modulatory activity of small molecules. Metabolomics and lipidomics screen for perturbations at the molecular level. The combination of these data-intensive comprehensive technologies is enabled by the rapid development of artificial intelligence. It promises a deep cellular and molecular phenotyping directly linked to chemical information about the applied drug candidates or complex mixtures.
650	1	4	_aCELL PAINTING
650	1	4	_aHIGH-CONTENT SCREENING
650	1	4	_aFUNCTIONAL METABOLOMICS
650	1	4	_aLIPIDOMICS
650	1	4	_aBIOACTIVES
650	1	4	_aDRUG DISCOVERY
700	1	2	_aXin, Z.
700	1	2	_aKupczyk, E.
700	1	2	_aSchmitt-Kopplin, P.
700	1	2	_aMueller, C.
856	4	0	_uhttps://drive.google.com/file/d/1DvQKgenv40Me4xvpxT3xzZv8PAlFpeUu/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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