000			01803nam a2200241Ia 4500
003			MX-MdCICY
005			20250625162437.0
040			_cCICY
090			_aB-19786
245	1	0	_aDereplication and Partial Identification of Natural Products
490	0		_vMethods in Biotechnology. Natural products isolation, 4, p.279-327, 1998
520	3		_aThis review summarizes the advances in dereplication technology since 1998, its current status, and the prospects for future development. Developments are being driven by the need to identify novel pharmaceutical and agrochemical lead compounds rapidly and effectively from complex natural matrices, while avoiding spending time or money on the re-isolation and re-identification of known natural products. As many commercial pharmaceuticals and agro-chemicals are at least derived from natural products, and only a small proportion of organisms has yet been examined for biologically active compounds, there is still enormous potential for the identification of many novel agents. In conjunction with modern screening methods, dereplication strategies must have high resolution, be sensitive, rapid, reproducible, and robust. Further, they must include effective data processing and information retrieval systems to permit comparison with internal and external sources of information on known compounds.
650	1	4	_aDEREPLICATION
650	1	4	_aSCREENING
650	1	4	_aNATURAL PRODUCTS
650	1	4	_aAGROCHEMICALS
650	1	4	_aPHARMACEUTICALS
700	1	2	_aMiddlesworth, F. V.
700	1	2	_aCannell, R. J.
856	4	0	_uhttps://drive.google.com/file/d/1G4riPu4ENTanl7t2dqcHHiVX4MwDmYbV/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c53905 _d53905