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090			_aB-19883
245	1	0	_aEssential Oil Composition, Antimicrobial and Pharmacological Activities of Lippia sidoides Cham. (Verbenaceae)From São Gonçalo do Abaeté, Minas Gerais, Brazil
490	0		_vPharmacognosy Magazine, 12(48), p.262, 2016
520	3		_aLippia sidoides (Verbenaceae)is used in Brazilian folk medicine as an antiseptic, and it is usually applied topically on skin, mucous membranes, mouth, and throat, or used for vaginal washings. Objectives: To analyze the chemical composition of the essential oil from L. sidoides collected in São Gonçalo do Abaeté, Minas Gerais and grown in Hidrolândia, Goiás; to evaluate the antimicrobial activity of the essential oil, crude etanol extract, and hexane, dichloromethane, ethyl-acetate, and aqueous fractions (AFs); to study the antinociceptive, anti-inflammatory, and central nervous system activities of the crude ethanol extract. Materials and methods: The essential oils were obtained by hydro-distillation using a Clevenger-type apparatus and analyzed by GC/MS. The antimicrobial activity in vitro was performed by broth microdilution method. The pharmacological tests were performed using female Swiss albino mice. Results: The major components of the essential oil were isoborneol (14.66 percent), bornyl acetate (11.86 percent), ?-humulene (11.23 percent), ?-fenchene (9.32 percent), and 1.8-cineole (7.05 percent), supporting the existence of two chemotypes of this species. The hexane fraction (HF)had good antifungal activity against Cryptococcus sp. ATCC D (MIC = 31.25 ?g/mL)and Cryptococcus gatti L48 (MIC = 62.5 ?g/mL). In the pharmacological tests, the crude ethanol extract presented antinociceptive and anti-inflammatory activities. Conclusion: Given that the ethanol extract of L. sidoides is included in the Formulary of Phytotherapeutic Agents of the Brazilian Pharmacopeia as an anti-inflammatory for oral cavities, the present work provides scientific evidence to back this use and highlight the importance of selecting the appropriate chemotype on the basis of the expected biological response.
650	1	4	_aANTI-INFLAMMATORY ACTIVITY
650	1	4	_aANTIMICROBIAL ACTIVITY
650	1	4	_aANTINOCICEPTIVE ACTIVITY
650	1	4	_aESSENTIAL OIL
650	1	4	_aLIPPIA SIDOIDES
700	1	2	_aDe Morais, S. R.
700	1	2	_aOliveira, T. L. S.
700	1	2	_aDe Oliveira, L. P.
700	1	2	_aTresvenzol, L. M. F.
700	1	2	_aDa Conceição, E. C.
700	1	2	_aRezende, M. H.
700	1	2	_aDe Paula, J. R.
856	4	0	_uhttps://drive.google.com/file/d/1YCmVIbsoT546UbOuc8ly2rVOLOjXORdO/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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